Assay Detail
Binding
CHEMBL4030281
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PTP1B (unknown origin) using pNPP as substrate pretreated for 10 mins followed by substrate addition measured after 20 mins by spectrophotometric method
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Tyrosine-protein phosphatase non-receptor type 1 (CHEMBL335) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Structure-related protein tyrosine phosphatase 1B inhibition by naringenin derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 4.58 | 5.27 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL169 | URSOLIC ACID | 2.0 | 1 | 5.27 |
| CHEMBL469654 | PRUNIN | — | 1 | 4.76 |
| CHEMBL446246 | NARIRUTIN | — | 1 | 4.25 |
| CHEMBL451532 | NARINGIN | — | 1 | 4.04 |
| CHEMBL9352 | NARINGENIN | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL169 | URSOLIC ACID | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL469654 | PRUNIN | IC50 | = | 17500.0 | nM | 4.76 |
| CHEMBL446246 | NARIRUTIN | IC50 | = | 56500.0 | nM | 4.25 |
| CHEMBL451532 | NARINGIN | IC50 | = | 91800.0 | nM | 4.04 |
| CHEMBL9352 | NARINGENIN | IC50 | = | 130100.0 | nM | - |