Assay Detail
Binding
CHEMBL4031136
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of C-terminal His-tagged full length Toxoplasma gondii CDPK1 expressed in Escherichia coli BL21 (DE3) using syntide-2 as substrate pre-incubated for 10 mins followed by ATP addition measured after 20 mins by ELISA
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Toxoplasma gondii |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Calmodulin-domain protein kinase 1 (CHEMBL1781862) ↗| Type | SINGLE PROTEIN |
| Organism | Toxoplasma gondii |
Publication
Inhibition of Calcium Dependent Protein Kinase 1 (CDPK1) by Pyrazolopyrimidine Analogs Decreases Establishment and Reoccurrence of Central Nervous System Disease by Toxoplasma gondii.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 28 | 7.48 | 8.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2324597 | — | — | 1 | 8.47 |
| CHEMBL4102392 | — | — | 1 | 8.13 |
| CHEMBL4078124 | — | — | 1 | 8.05 |
| CHEMBL4087915 | — | — | 1 | 8.00 |
| CHEMBL4098707 | — | — | 1 | 7.99 |
| CHEMBL4086945 | — | — | 1 | 7.99 |
| CHEMBL4069991 | — | — | 1 | 7.96 |
| CHEMBL4094646 | — | — | 1 | 7.87 |
| CHEMBL4074754 | — | — | 1 | 7.87 |
| CHEMBL4065764 | — | — | 1 | 7.86 |
| CHEMBL4093769 | — | — | 1 | 7.85 |
| CHEMBL4096137 | — | — | 1 | 7.84 |
| CHEMBL4098582 | — | — | 1 | 7.79 |
| CHEMBL4090858 | — | — | 1 | 7.72 |
| CHEMBL2324593 | — | — | 1 | 7.50 |
| CHEMBL4097112 | — | — | 1 | 7.45 |
| CHEMBL4065140 | — | — | 1 | 7.33 |
| CHEMBL4088534 | — | — | 1 | 7.33 |
| CHEMBL4095218 | — | — | 1 | 7.17 |
| CHEMBL4060191 | — | — | 1 | 7.14 |
| CHEMBL4090973 | — | — | 1 | 7.11 |
| CHEMBL4080665 | — | — | 1 | 7.02 |
| CHEMBL4073069 | — | — | 1 | 6.93 |
| CHEMBL4080552 | — | — | 1 | 6.76 |
| CHEMBL4067196 | — | — | 1 | 6.72 |
| CHEMBL4068845 | — | — | 1 | 6.66 |
| CHEMBL4088414 | — | — | 1 | 6.57 |
| CHEMBL4069866 | — | — | 1 | 6.29 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2324597 | — | IC50 | = | 3.38 | nM | 8.47 |
| CHEMBL4102392 | — | IC50 | = | 7.49 | nM | 8.13 |
| CHEMBL4078124 | — | IC50 | = | 8.94 | nM | 8.05 |
| CHEMBL4087915 | — | IC50 | = | 9.99 | nM | 8.00 |
| CHEMBL4098707 | — | IC50 | = | 10.2 | nM | 7.99 |
| CHEMBL4086945 | — | IC50 | = | 10.32 | nM | 7.99 |
| CHEMBL4069991 | — | IC50 | = | 10.9 | nM | 7.96 |
| CHEMBL4094646 | — | IC50 | = | 13.56 | nM | 7.87 |
| CHEMBL4074754 | — | IC50 | = | 13.53 | nM | 7.87 |
| CHEMBL4065764 | — | IC50 | = | 13.79 | nM | 7.86 |
| CHEMBL4093769 | — | IC50 | = | 14.15 | nM | 7.85 |
| CHEMBL4096137 | — | IC50 | = | 14.53 | nM | 7.84 |
| CHEMBL4098582 | — | IC50 | = | 16.4 | nM | 7.79 |
| CHEMBL4090858 | — | IC50 | = | 19.2 | nM | 7.72 |
| CHEMBL2324593 | — | IC50 | = | 31.86 | nM | 7.50 |
| CHEMBL4097112 | — | IC50 | = | 35.12 | nM | 7.45 |
| CHEMBL4065140 | — | IC50 | = | 46.98 | nM | 7.33 |
| CHEMBL4088534 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL4095218 | — | IC50 | = | 67.5 | nM | 7.17 |
| CHEMBL4060191 | — | IC50 | = | 73.09 | nM | 7.14 |
| CHEMBL4090973 | — | IC50 | = | 77.5 | nM | 7.11 |
| CHEMBL4080665 | — | IC50 | = | 95.3 | nM | 7.02 |
| CHEMBL4073069 | — | IC50 | = | 118.6 | nM | 6.93 |
| CHEMBL4080552 | — | IC50 | = | 173.0 | nM | 6.76 |
| CHEMBL4067196 | — | IC50 | = | 190.6 | nM | 6.72 |
| CHEMBL4068845 | — | IC50 | = | 218.5 | nM | 6.66 |
| CHEMBL4088414 | — | IC50 | = | 271.9 | nM | 6.57 |
| CHEMBL4069866 | — | IC50 | = | 517.0 | nM | 6.29 |