Assay Detail
Functional
CHEMBL4031331
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Antiproliferative activity against human HCT116 cells after 72 hrs by MTT assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design and Synthesis of Ligand Efficient Dual Inhibitors of Janus Kinase (JAK) and Histone Deacetylase (HDAC) Based on Ruxolitinib and Vorinostat.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 4.97 | 5.73 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 5.73 |
| CHEMBL2018302 | TUBASTATIN A | — | 1 | 5.70 |
| CHEMBL4060201 | — | — | 1 | 5.63 |
| CHEMBL4060602 | — | — | 1 | 5.05 |
| CHEMBL4069283 | — | — | 1 | 4.93 |
| CHEMBL4098975 | — | — | 1 | 4.71 |
| CHEMBL4091233 | — | — | 1 | 4.64 |
| CHEMBL4059703 | — | — | 1 | 4.60 |
| CHEMBL4070306 | — | — | 1 | 4.39 |
| CHEMBL4088824 | — | — | 1 | 4.33 |
| CHEMBL4089113 | — | — | 1 | - |
| CHEMBL4084049 | — | — | 1 | - |
| CHEMBL1789941 | RUXOLITINIB | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL98 | VORINOSTAT | IC50 | = | 1850.0 | nM | 5.73 |
| CHEMBL2018302 | TUBASTATIN A | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL4060201 | — | IC50 | = | 2320.0 | nM | 5.63 |
| CHEMBL4060602 | — | IC50 | = | 8990.0 | nM | 5.05 |
| CHEMBL4069283 | — | IC50 | = | 11800.0 | nM | 4.93 |
| CHEMBL4098975 | — | IC50 | = | 19400.0 | nM | 4.71 |
| CHEMBL4091233 | — | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL4059703 | — | IC50 | = | 25300.0 | nM | 4.60 |
| CHEMBL4070306 | — | IC50 | = | 41100.0 | nM | 4.39 |
| CHEMBL4088824 | — | IC50 | = | 46200.0 | nM | 4.33 |
| CHEMBL4089113 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4084049 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1789941 | RUXOLITINIB | IC50 | > | 10000.0 | nM | - |