Assay Detail
ADMET
CHEMBL4031740
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Cytotoxicity against human BT474 cells assessed as reduction in cell viability after 3 days by CellTiter-Glo assay
39
Total Activities
39
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | BT-474 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
The Discovery of a Dual TTK Protein Kinase/CDC2-Like Kinase (CLK2) Inhibitor for the Treatment of Triple Negative Breast Cancer Initiated from a Phenotypic Screen.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 39 | 5.31 | 6.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4098047 | — | — | 1 | 6.80 |
| CHEMBL4078291 | — | — | 1 | 6.61 |
| CHEMBL4075857 | — | — | 1 | 6.16 |
| CHEMBL4093026 | — | — | 1 | 6.13 |
| CHEMBL4090966 | — | — | 1 | 6.05 |
| CHEMBL4066315 | — | — | 1 | 6.02 |
| CHEMBL4095765 | — | — | 1 | 5.87 |
| CHEMBL4088669 | — | — | 1 | 5.76 |
| CHEMBL4066568 | — | — | 1 | 5.49 |
| CHEMBL4068490 | — | — | 1 | 5.48 |
| CHEMBL4097084 | — | — | 1 | 5.42 |
| CHEMBL4071138 | — | — | 1 | 5.42 |
| CHEMBL4066617 | — | — | 1 | 5.31 |
| CHEMBL4065773 | — | — | 1 | 5.21 |
| CHEMBL4077306 | — | — | 1 | 5.19 |
| CHEMBL4062218 | — | — | 1 | 5.16 |
| CHEMBL4060730 | — | — | 1 | 5.09 |
| CHEMBL4091034 | — | — | 1 | 5.08 |
| CHEMBL4092644 | — | — | 1 | 5.02 |
| CHEMBL4086597 | — | — | 1 | 5.00 |
| CHEMBL4078595 | — | — | 1 | 5.00 |
| CHEMBL4076181 | — | — | 1 | 5.00 |
| CHEMBL4066729 | — | — | 1 | 5.00 |
| CHEMBL4063994 | — | — | 1 | 5.00 |
| CHEMBL4080975 | — | — | 1 | 5.00 |
| CHEMBL4086004 | — | — | 1 | 5.00 |
| CHEMBL4063632 | — | — | 1 | 5.00 |
| CHEMBL4090356 | — | — | 1 | 5.00 |
| CHEMBL4061555 | — | — | 1 | 5.00 |
| CHEMBL4060209 | — | — | 1 | 5.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4098047 | — | IC50 | = | 158.0 | nM | 6.80 |
| CHEMBL4078291 | — | IC50 | = | 243.0 | nM | 6.61 |
| CHEMBL4075857 | — | IC50 | = | 694.0 | nM | 6.16 |
| CHEMBL4093026 | — | IC50 | = | 739.0 | nM | 6.13 |
| CHEMBL4090966 | — | IC50 | = | 893.0 | nM | 6.05 |
| CHEMBL4066315 | — | IC50 | = | 946.0 | nM | 6.02 |
| CHEMBL4095765 | — | IC50 | = | 1350.0 | nM | 5.87 |
| CHEMBL4088669 | — | IC50 | = | 1730.0 | nM | 5.76 |
| CHEMBL4066568 | — | IC50 | = | 3210.0 | nM | 5.49 |
| CHEMBL4068490 | — | IC50 | = | 3320.0 | nM | 5.48 |
| CHEMBL4097084 | — | IC50 | = | 3760.0 | nM | 5.42 |
| CHEMBL4071138 | — | IC50 | = | 3760.0 | nM | 5.42 |
| CHEMBL4066617 | — | IC50 | = | 4860.0 | nM | 5.31 |
| CHEMBL4065773 | — | IC50 | = | 6090.0 | nM | 5.21 |
| CHEMBL4077306 | — | IC50 | = | 6390.0 | nM | 5.19 |
| CHEMBL4062218 | — | IC50 | = | 6970.0 | nM | 5.16 |
| CHEMBL4060730 | — | IC50 | = | 8120.0 | nM | 5.09 |
| CHEMBL4091034 | — | IC50 | = | 8310.0 | nM | 5.08 |
| CHEMBL4092644 | — | IC50 | = | 9610.0 | nM | 5.02 |
| CHEMBL4064411 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL4063065 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL4068276 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL4074116 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL4099734 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL4061354 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL4080238 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL4061401 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL4086674 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL4060209 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL4061555 | — | IC50 | = | 9910.0 | nM | 5.00 |
| CHEMBL4090356 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL4063632 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL4086004 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL4080975 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL4063994 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL4066729 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL4076181 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL4078595 | — | IC50 | = | 9990.0 | nM | 5.00 |
| CHEMBL4086597 | — | IC50 | = | 10000.0 | nM | 5.00 |