Assay Detail
Binding
CHEMBL4032161
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human neuronal NOS expressed in Escherichia coli using L-arginine as substrate assessed as reduction in NO production by measuring oxidation of oxyHb to metHb measured for 6 mins by hemoglobin- NO capture assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Improvement of Cell Permeability of Human Neuronal Nitric Oxide Synthase Inhibitors Using Potent and Selective 2-Aminopyridine-Based Scaffolds with a Fluorobenzene Linker.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 14 | 7.03 | 7.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3818373 | — | — | 1 | 7.89 |
| CHEMBL4094689 | — | — | 1 | 7.52 |
| CHEMBL4074188 | — | — | 1 | 7.37 |
| CHEMBL4103382 | — | — | 1 | 7.26 |
| CHEMBL4079135 | — | — | 1 | 7.19 |
| CHEMBL4071288 | — | — | 1 | 7.09 |
| CHEMBL4062639 | — | — | 1 | 7.08 |
| CHEMBL4084332 | — | — | 1 | 7.00 |
| CHEMBL4061573 | — | — | 1 | 6.44 |
| CHEMBL4086997 | — | — | 1 | 6.29 |
| CHEMBL4065564 | — | — | 1 | 6.22 |
| CHEMBL4084484 | — | — | 1 | - |
| CHEMBL4102437 | — | — | 1 | - |
| CHEMBL4092089 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3818373 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL4094689 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL4074188 | — | Ki | = | 43.0 | nM | 7.37 |
| CHEMBL4103382 | — | Ki | = | 55.0 | nM | 7.26 |
| CHEMBL4079135 | — | Ki | = | 65.0 | nM | 7.19 |
| CHEMBL4071288 | — | Ki | = | 82.0 | nM | 7.09 |
| CHEMBL4062639 | — | Ki | = | 83.0 | nM | 7.08 |
| CHEMBL4084332 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL4061573 | — | Ki | = | 362.0 | nM | 6.44 |
| CHEMBL4086997 | — | Ki | = | 516.0 | nM | 6.29 |
| CHEMBL4065564 | — | Ki | = | 598.0 | nM | 6.22 |
| CHEMBL4084484 | — | Ki | - | — | - | |
| CHEMBL4102437 | — | Ki | - | — | - | |
| CHEMBL4092089 | — | Ki | - | — | - |