Assay Detail
ADMET
CHEMBL4032164
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Inhibition of mouse macrophage iNOS expressed in Escherichia coli using L-arginine as substrate assessed as reduction in NO production by measuring oxidation of oxyHb to metHb measured for 6 mins by hemoglobin- NO capture assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Mus musculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Improvement of Cell Permeability of Human Neuronal Nitric Oxide Synthase Inhibitors Using Potent and Selective 2-Aminopyridine-Based Scaffolds with a Fluorobenzene Linker.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 14 | 5.17 | 5.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3818373 | — | — | 1 | 5.72 |
| CHEMBL4071288 | — | — | 1 | 5.52 |
| CHEMBL4062639 | — | — | 1 | 5.52 |
| CHEMBL4074188 | — | — | 1 | 5.46 |
| CHEMBL4103382 | — | — | 1 | 5.44 |
| CHEMBL4094689 | — | — | 1 | 5.41 |
| CHEMBL4084332 | — | — | 1 | 5.38 |
| CHEMBL4079135 | — | — | 1 | 5.33 |
| CHEMBL4092089 | — | — | 1 | 5.17 |
| CHEMBL4061573 | — | — | 1 | 4.96 |
| CHEMBL4086997 | — | — | 1 | 4.79 |
| CHEMBL4102437 | — | — | 1 | 4.79 |
| CHEMBL4065564 | — | — | 1 | 4.47 |
| CHEMBL4084484 | — | — | 1 | 4.44 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3818373 | — | Ki | = | 1894.0 | nM | 5.72 |
| CHEMBL4071288 | — | Ki | = | 3005.0 | nM | 5.52 |
| CHEMBL4062639 | — | Ki | = | 3012.0 | nM | 5.52 |
| CHEMBL4074188 | — | Ki | = | 3458.0 | nM | 5.46 |
| CHEMBL4103382 | — | Ki | = | 3614.0 | nM | 5.44 |
| CHEMBL4094689 | — | Ki | = | 3857.0 | nM | 5.41 |
| CHEMBL4084332 | — | Ki | = | 4213.0 | nM | 5.38 |
| CHEMBL4079135 | — | Ki | = | 4649.0 | nM | 5.33 |
| CHEMBL4092089 | — | Ki | = | 6704.0 | nM | 5.17 |
| CHEMBL4061573 | — | Ki | = | 10883.0 | nM | 4.96 |
| CHEMBL4086997 | — | Ki | = | 16165.0 | nM | 4.79 |
| CHEMBL4102437 | — | Ki | = | 16373.0 | nM | 4.79 |
| CHEMBL4065564 | — | Ki | = | 33690.0 | nM | 4.47 |
| CHEMBL4084484 | — | Ki | = | 36017.0 | nM | 4.44 |