Assay Detail
ADMET
CHEMBL4032273
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Agonist activity at human S1P3 receptor expressed in CHO-K1 cells assessed as increase in S1P-stimulated calcium influx preincubated for 5 mins followed by S1P stimulation measured every 3 secs by fluorescence method
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of a 1-Methyl-3,4-dihydronaphthalene-Based Sphingosine-1-Phosphate (S1P) Receptor Agonist Ceralifimod (ONO-4641). A S1P1 and S1P5 Selective Agonist for the Treatment of Autoimmune Diseases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 22 | 5.23 | 5.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4095501 | — | — | 1 | 5.40 |
| CHEMBL1962532 | — | — | 1 | 5.30 |
| CHEMBL4093077 | — | — | 1 | 5.26 |
| CHEMBL4074505 | — | — | 1 | 5.17 |
| CHEMBL4085321 | — | — | 1 | 5.03 |
| CHEMBL4059628 | — | — | 1 | - |
| CHEMBL4095920 | — | — | 1 | - |
| CHEMBL4077888 | — | — | 1 | - |
| CHEMBL4101237 | — | — | 1 | - |
| CHEMBL4065871 | — | — | 1 | - |
| CHEMBL4093489 | — | — | 1 | - |
| CHEMBL4092538 | — | — | 1 | - |
| CHEMBL4071753 | — | — | 1 | - |
| CHEMBL4084786 | — | — | 1 | - |
| CHEMBL4087932 | — | — | 1 | - |
| CHEMBL4075067 | — | — | 1 | - |
| CHEMBL4103252 | — | — | 1 | - |
| CHEMBL4065407 | — | — | 1 | - |
| CHEMBL4100785 | — | — | 1 | - |
| CHEMBL4074023 | — | — | 1 | - |
| CHEMBL4062652 | — | — | 1 | - |
| CHEMBL4063139 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4095501 | — | EC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL1962532 | — | EC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL4093077 | — | EC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL4074505 | — | EC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL4085321 | — | EC50 | = | 9300.0 | nM | 5.03 |
| CHEMBL4059628 | — | EC50 | > | 30000.0 | nM | - |
| CHEMBL4095920 | — | EC50 | > | 30000.0 | nM | - |
| CHEMBL4077888 | — | EC50 | > | 30000.0 | nM | - |
| CHEMBL4101237 | — | EC50 | > | 30000.0 | nM | - |
| CHEMBL4065871 | — | EC50 | > | 30000.0 | nM | - |
| CHEMBL4093489 | — | EC50 | > | 30000.0 | nM | - |
| CHEMBL4092538 | — | EC50 | > | 30000.0 | nM | - |
| CHEMBL4071753 | — | EC50 | > | 30000.0 | nM | - |
| CHEMBL4084786 | — | EC50 | > | 30000.0 | nM | - |
| CHEMBL4087932 | — | EC50 | > | 30000.0 | nM | - |
| CHEMBL4075067 | — | EC50 | > | 30000.0 | nM | - |
| CHEMBL4103252 | — | EC50 | > | 30000.0 | nM | - |
| CHEMBL4065407 | — | EC50 | > | 30000.0 | nM | - |
| CHEMBL4100785 | — | EC50 | > | 30000.0 | nM | - |
| CHEMBL4074023 | — | EC50 | > | 30000.0 | nM | - |
| CHEMBL4062652 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4063139 | — | EC50 | > | 30000.0 | nM | - |