Assay Detail
Binding
CHEMBL4032332
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human erythrocytes LDHB using sodium pyruvate as substrate after 5 mins in presence of NAPDH by diaphorase/resazurin based fluorescence assay
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery and Optimization of Potent, Cell-Active Pyrazole-Based Inhibitors of Lactate Dehydrogenase (LDH).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 6.72 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4059985 | — | — | 1 | 8.10 |
| CHEMBL4100845 | — | — | 1 | 7.70 |
| CHEMBL4090677 | — | — | 1 | 7.70 |
| CHEMBL4081890 | — | — | 1 | 7.57 |
| CHEMBL4080497 | — | — | 1 | 7.31 |
| CHEMBL4101800 | — | — | 1 | 7.21 |
| CHEMBL4075666 | — | — | 1 | 7.12 |
| CHEMBL4076027 | — | — | 1 | 7.11 |
| CHEMBL4076958 | — | — | 1 | 7.02 |
| CHEMBL4082867 | — | — | 1 | 6.92 |
| CHEMBL4069796 | — | — | 1 | 6.89 |
| CHEMBL4090794 | — | — | 1 | 6.69 |
| CHEMBL4066429 | — | — | 1 | 6.59 |
| CHEMBL4063125 | — | — | 1 | 6.37 |
| CHEMBL4065858 | — | — | 1 | 6.36 |
| CHEMBL4076973 | — | — | 1 | 6.14 |
| CHEMBL4099443 | — | — | 1 | 6.04 |
| CHEMBL3335794 | — | — | 1 | 5.94 |
| CHEMBL4084774 | — | — | 1 | 5.82 |
| CHEMBL4092360 | — | — | 1 | 5.55 |
| CHEMBL2059811 | — | — | 1 | 5.04 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4059985 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL4100845 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL4090677 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL4081890 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL4080497 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL4101800 | — | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL4075666 | — | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL4076027 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL4076958 | — | IC50 | = | 96.0 | nM | 7.02 |
| CHEMBL4082867 | — | IC50 | = | 119.0 | nM | 6.92 |
| CHEMBL4069796 | — | IC50 | = | 129.0 | nM | 6.89 |
| CHEMBL4090794 | — | IC50 | = | 204.0 | nM | 6.69 |
| CHEMBL4066429 | — | IC50 | = | 259.0 | nM | 6.59 |
| CHEMBL4063125 | — | IC50 | = | 424.0 | nM | 6.37 |
| CHEMBL4065858 | — | IC50 | = | 441.0 | nM | 6.36 |
| CHEMBL4076973 | — | IC50 | = | 724.0 | nM | 6.14 |
| CHEMBL4099443 | — | IC50 | = | 911.0 | nM | 6.04 |
| CHEMBL3335794 | — | IC50 | = | 1150.0 | nM | 5.94 |
| CHEMBL4084774 | — | IC50 | = | 1510.0 | nM | 5.82 |
| CHEMBL4092360 | — | IC50 | = | 2820.0 | nM | 5.55 |
| CHEMBL2059811 | — | IC50 | = | 9200.0 | nM | 5.04 |