Assay Detail
Binding
CHEMBL4032434
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human NMT1 using [3H]-myristoyl-coA/biotinylated CAP5.5 as substrate after 15 mins by scintillation/luminescence counting method
38
Total Activities
38
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Glycylpeptide N-tetradecanoyltransferase 1 (CHEMBL2593) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design and Synthesis of Brain Penetrant Trypanocidal N-Myristoyltransferase Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 38 | 6.55 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1230468 | — | — | 1 | 8.40 |
| CHEMBL3358120 | — | — | 1 | 8.30 |
| CHEMBL4080376 | — | — | 1 | 8.00 |
| CHEMBL3358114 | — | — | 1 | 7.92 |
| CHEMBL4069661 | — | — | 1 | 7.52 |
| CHEMBL4071314 | — | — | 1 | 7.52 |
| CHEMBL4096886 | — | — | 1 | 7.40 |
| CHEMBL4104613 | — | — | 1 | 7.40 |
| CHEMBL4080389 | — | — | 1 | 7.40 |
| CHEMBL4096874 | — | — | 1 | 7.22 |
| CHEMBL4062072 | — | — | 1 | 7.10 |
| CHEMBL4090626 | — | — | 1 | 7.10 |
| CHEMBL4099270 | — | — | 1 | 7.05 |
| CHEMBL4088228 | — | — | 1 | 7.00 |
| CHEMBL4061001 | — | — | 1 | 6.75 |
| CHEMBL4069679 | — | — | 1 | 6.70 |
| CHEMBL4081852 | — | — | 1 | 6.70 |
| CHEMBL4101887 | — | — | 1 | 6.52 |
| CHEMBL4083888 | — | — | 1 | 6.52 |
| CHEMBL4076087 | — | — | 1 | 6.52 |
| CHEMBL4089716 | — | — | 1 | 6.30 |
| CHEMBL4068594 | — | — | 1 | 6.16 |
| CHEMBL4077369 | — | — | 1 | 6.05 |
| CHEMBL4078895 | — | — | 1 | 6.05 |
| CHEMBL4062043 | — | — | 1 | 6.00 |
| CHEMBL4065925 | — | — | 1 | 5.89 |
| CHEMBL4095958 | — | — | 1 | 5.75 |
| CHEMBL4087726 | — | — | 1 | 5.42 |
| CHEMBL4062669 | — | — | 1 | 5.36 |
| CHEMBL4093525 | — | — | 1 | 5.19 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1230468 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL3358120 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL4080376 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL3358114 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL4069661 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL4071314 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL4096886 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL4104613 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL4080389 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL4096874 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL4062072 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL4090626 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL4099270 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL4088228 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL4061001 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL4069679 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL4081852 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL4076087 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL4101887 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL4083888 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL4089716 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL4068594 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL4077369 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL4078895 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL4062043 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL4065925 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL4095958 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL4087726 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL4062669 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL4093525 | — | IC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL4103178 | — | IC50 | = | 9900.0 | nM | 5.00 |
| CHEMBL4105605 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL4094965 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL4067547 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL4098349 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4076386 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4059932 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4075895 | — | IC50 | > | 50000.0 | nM | - |