Compound Detail
CHEMBL4096874
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL4096874 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | XNXMVXYKLZWGAU-UHFFFAOYSA-N |
4
Targets
4
Activities
2
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
378.4
MW (Da)
3.58
ALogP
5
HBA
1
HBD
50.3
PSA (Ų)
0.74
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 2 meas. best 5.62
IC50 2 meas. best 7.22
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Glycylpeptide N-tetradecanoyltransferase 1 CHEMBL2593 | IC50 | 7.22 | 7.22 | 60.0 | 1 |
| Unchecked CHEMBL612545 | IC50 | 5.92 | 5.92 | 1200.0 | 1 |
| Trypanosoma brucei brucei CHEMBL612851 | EC50 | 5.62 | 5.62 | 2400.0 | 1 |
| MRC5 CHEMBL614181 | EC50 | 5.48 | 5.48 | 3300.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Glycylpeptide N-tetradecanoyltransferase 1 | IC50 | = | 60.0 | nM | 7.22 | Inhibition of human NMT1 using [3H]-myristoyl-coA/biotinylated CAP5.5 as substra... | 29125744 |
| Unchecked | IC50 | = | 1200.0 | nM | 5.92 | Inhibition of Trypanosoma brucei NMT using [3H]-myristoyl-coA/biotinylated CAP5.... | 29125744 |
| Trypanosoma brucei brucei | EC50 | = | 2400.0 | nM | 5.62 | Trypanocidal activity against bloodstream form of Trypanosoma brucei brucei s427... | 29125744 |
| MRC5 | EC50 | = | 3300.0 | nM | 5.48 | CYtotoxicity against human MRC5 cells after 69 hrs by resazurin assay | 29125744 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 29125744 | 10.1021/acs.jmedchem.7b01255 | Unchecked | 2 |
| 29125744 | 10.1021/acs.jmedchem.7b01255 | Trypanosoma brucei brucei | 1 |
| 29125744 | 10.1021/acs.jmedchem.7b01255 | Glycylpeptide N-tetradecanoyltransferase 1 | 1 |
| 29125744 | 10.1021/acs.jmedchem.7b01255 | MRC5 | 1 |
Data from ChEMBL 36 via Core Engine