Assay Detail
ADMET
CHEMBL4032436
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CYtotoxicity against human MRC5 cells after 69 hrs by resazurin assay
38
Total Activities
38
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | MRC5 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design and Synthesis of Brain Penetrant Trypanocidal N-Myristoyltransferase Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 38 | 5.58 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3358120 | — | — | 1 | 6.70 |
| CHEMBL1230468 | — | — | 1 | 6.40 |
| CHEMBL3358114 | — | — | 1 | 6.00 |
| CHEMBL4061001 | — | — | 1 | 5.85 |
| CHEMBL4080376 | — | — | 1 | 5.82 |
| CHEMBL4104613 | — | — | 1 | 5.82 |
| CHEMBL4087726 | — | — | 1 | 5.70 |
| CHEMBL4069679 | — | — | 1 | 5.68 |
| CHEMBL4090626 | — | — | 1 | 5.66 |
| CHEMBL4081852 | — | — | 1 | 5.64 |
| CHEMBL4069661 | — | — | 1 | 5.60 |
| CHEMBL4065925 | — | — | 1 | 5.55 |
| CHEMBL4067547 | — | — | 1 | 5.51 |
| CHEMBL4096874 | — | — | 1 | 5.48 |
| CHEMBL4062669 | — | — | 1 | 5.46 |
| CHEMBL4083888 | — | — | 1 | 5.43 |
| CHEMBL4093525 | — | — | 1 | 5.34 |
| CHEMBL4099270 | — | — | 1 | 5.30 |
| CHEMBL4062043 | — | — | 1 | 5.20 |
| CHEMBL4101887 | — | — | 1 | 5.17 |
| CHEMBL4062072 | — | — | 1 | 5.06 |
| CHEMBL4095958 | — | — | 1 | 5.05 |
| CHEMBL4080389 | — | — | 1 | 4.85 |
| CHEMBL4088228 | — | — | 1 | - |
| CHEMBL4096886 | — | — | 1 | - |
| CHEMBL4075895 | — | — | 1 | - |
| CHEMBL4076386 | — | — | 1 | - |
| CHEMBL4105605 | — | — | 1 | - |
| CHEMBL4068594 | — | — | 1 | - |
| CHEMBL4077369 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3358120 | — | EC50 | = | 200.0 | nM | 6.70 |
| CHEMBL1230468 | — | EC50 | = | 400.0 | nM | 6.40 |
| CHEMBL3358114 | — | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL4061001 | — | EC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL4080376 | — | EC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL4104613 | — | EC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL4087726 | — | EC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL4069679 | — | EC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL4090626 | — | EC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL4081852 | — | EC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL4069661 | — | EC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL4065925 | — | EC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL4067547 | — | EC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL4096874 | — | EC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL4062669 | — | EC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL4083888 | — | EC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL4093525 | — | EC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL4099270 | — | EC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL4062043 | — | EC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL4101887 | — | EC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL4062072 | — | EC50 | = | 8700.0 | nM | 5.06 |
| CHEMBL4095958 | — | EC50 | = | 8900.0 | nM | 5.05 |
| CHEMBL4080389 | — | EC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL4089716 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL4059932 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL4071314 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4098349 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL4094965 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4103178 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL4078895 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL4076087 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL4077369 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL4068594 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL4105605 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4076386 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL4075895 | — | EC50 | > | 50000.0 | nM | - |
| CHEMBL4096886 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL4088228 | — | EC50 | > | 1000.0 | nM | - |