Assay Detail
Binding
CHEMBL4032443
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]8-OH-DPAT from human 5-HT1A receptor expressed in CHO-K1 cell membranes after 60 mins by scintillation counting method
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Highly Selective Dopamine D3 Receptor Antagonists with Arylated Diazaspiro Alkane Cores.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 7.02 | 9.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4083252 | — | — | 1 | 9.66 |
| CHEMBL4073927 | — | — | 1 | 6.23 |
| CHEMBL4062553 | — | — | 1 | 6.14 |
| CHEMBL4084262 | — | — | 1 | 6.03 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4083252 | — | Ki | = | 0.22 | nM | 9.66 |
| CHEMBL4073927 | — | Ki | = | 587.0 | nM | 6.23 |
| CHEMBL4062553 | — | Ki | = | 724.0 | nM | 6.14 |
| CHEMBL4084262 | — | Ki | = | 931.0 | nM | 6.03 |