Assay Detail
Functional
CHEMBL4032482
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Antiproliferative activity against human SH-SY5Y cells after 24 hrs by MTT assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SH-SY5Y |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design of Novel 3-Pyrimidinylazaindole CDK2/9 Inhibitors with Potent In Vitro and In Vivo Antitumor Efficacy in a Triple-Negative Breast Cancer Model.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.14 | 6.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL270686 | MERIOLIN 3 | — | 1 | 6.92 |
| CHEMBL4068858 | — | — | 1 | 6.40 |
| CHEMBL4095226 | — | — | 1 | 6.10 |
| CHEMBL4089950 | — | — | 1 | 6.05 |
| CHEMBL4065940 | — | — | 1 | 6.05 |
| CHEMBL4074567 | — | — | 1 | 6.00 |
| CHEMBL4101278 | — | — | 1 | 5.48 |
| CHEMBL4098661 | — | — | 1 | - |
| CHEMBL4063017 | — | — | 1 | - |
| CHEMBL405665 | MERIOLIN 1 | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL270686 | MERIOLIN 3 | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL4068858 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL4095226 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL4089950 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL4065940 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL4074567 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL4101278 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL4098661 | — | IC50 | - | — | - | |
| CHEMBL4063017 | — | IC50 | - | — | - | |
| CHEMBL405665 | MERIOLIN 1 | IC50 | - | — | - |