Assay Detail
Binding
CHEMBL4032874
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of P300/CBP in human MV4-11 cells assessed as reduction in MYC expression after 4 hrs by luminescence based assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
CREB-binding protein/Histone acetyltransferase p300 (CHEMBL3883300) ↗| Type | PROTEIN FAMILY |
| Organism | Homo sapiens |
Publication
A Unique Approach to Design Potent and Selective Cyclic Adenosine Monophosphate Response Element Binding Protein, Binding Protein (CBP) Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 6.66 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4095153 | — | — | 1 | 7.92 |
| CHEMBL4061254 | — | — | 1 | 7.28 |
| CHEMBL4073812 | — | — | 1 | 6.44 |
| CHEMBL4072630 | — | — | 1 | 6.00 |
| CHEMBL4065346 | — | — | 1 | 5.66 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4095153 | — | EC50 | = | 12.0 | nM | 7.92 |
| CHEMBL4061254 | — | EC50 | = | 53.0 | nM | 7.28 |
| CHEMBL4073812 | — | EC50 | = | 360.0 | nM | 6.44 |
| CHEMBL4072630 | — | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL4065346 | — | EC50 | = | 2200.0 | nM | 5.66 |