Assay Detail
Binding
CHEMBL4033941
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Escherichia coli DNA gyrase using relaxed pBR322 DNA as substrate by agarose gel electrophorosis method
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Escherichia coli |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Covalently linked kanamycin - Ciprofloxacin hybrid antibiotics as a tool to fight bacterial resistance.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.43 | 5.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL8 | CIPROFLOXACIN | 4.0 | 1 | 5.89 |
| CHEMBL4081574 | — | — | 1 | 5.58 |
| CHEMBL4074141 | — | — | 1 | 5.23 |
| CHEMBL4064500 | — | — | 1 | 5.00 |
| CHEMBL1384 | KANAMYCIN | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL8 | CIPROFLOXACIN | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL4081574 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL4074141 | — | IC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL4064500 | — | IC50 | = | 9900.0 | nM | 5.00 |
| CHEMBL1384 | KANAMYCIN | IC50 | - | — | - |