Assay Detail
Binding
CHEMBL4033942
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Escherichia coli topoisomerase 4 using supercoiled pBR322 DNA as substrate by agarose gel electrophorosis method
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Escherichia coli |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Covalently linked kanamycin - Ciprofloxacin hybrid antibiotics as a tool to fight bacterial resistance.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 4.96 | 5.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4081574 | — | — | 1 | 5.10 |
| CHEMBL8 | CIPROFLOXACIN | 4.0 | 1 | 5.07 |
| CHEMBL4074141 | — | — | 1 | 4.70 |
| CHEMBL1384 | KANAMYCIN | 4.0 | 1 | - |
| CHEMBL4064500 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4081574 | — | IC50 | = | 7900.0 | nM | 5.10 |
| CHEMBL8 | CIPROFLOXACIN | IC50 | = | 8600.0 | nM | 5.07 |
| CHEMBL4074141 | — | IC50 | = | 19800.0 | nM | 4.70 |
| CHEMBL1384 | KANAMYCIN | IC50 | - | — | - | |
| CHEMBL4064500 | — | IC50 | > | 100000.0 | nM | - |