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Assay Detail

CHEMBL4034203

Review assay metadata, readout intent, target linkage, and publication context from the same page.

ADMET
Inhibition of Sprague-Dawley rat kidney ALR1 using sodium D-glucuronate as substrate by spectrophotometric method
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type ADMET
Organism Rattus norvegicus
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Aldo-keto reductase family 1 member B1 (CHEMBL2622)
Type SINGLE PROTEIN
Organism Rattus norvegicus

Publication

N-(Aroyl)-N-(arylmethyloxy)-α-alanines: Selective inhibitors of aldose reductase.
Nencetti S, La Motta C, Rossello A, Sartini S, Nuti E, Ciccone L, Orlandini E.
Bioorg Med Chem (2017) 25 : 3068 -3076
PubMed 28392277 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 10 7.54 7.54

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL266497 SORBINIL 3.0 1 7.54
CHEMBL4083683 1 -
CHEMBL4061922 1 -
CHEMBL4091462 1 -
CHEMBL4070547 1 -
CHEMBL4099195 1 -
CHEMBL4081169 1 -
CHEMBL4060849 1 -
CHEMBL4089048 1 -
CHEMBL436 TOLRESTAT 4.0 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL266497 SORBINIL IC50 = 29.0 nM 7.54
CHEMBL4083683 IC50 > 100000.0 nM -
CHEMBL4061922 IC50 > 100000.0 nM -
CHEMBL4091462 IC50 > 100000.0 nM -
CHEMBL4070547 IC50 > 100000.0 nM -
CHEMBL4099195 IC50 > 100000.0 nM -
CHEMBL4081169 IC50 > 100000.0 nM -
CHEMBL4060849 IC50 > 100000.0 nM -
CHEMBL4089048 IC50 > 100000.0 nM -
CHEMBL436 TOLRESTAT IC50 > 100000.0 nM -