Assay Detail
Binding
CHEMBL4034243
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Induction of nuclear translocation of human GFP-tagged NFATc1 expressed in virus infected primary human skeletal muscle myoblasts after 3 hrs by DAPI staining based assay
33
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Nuclear factor of activated T-cells, cytoplasmic 1 (CHEMBL3876) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Developing DYRK inhibitors derived from the meridianins as a means of increasing levels of NFAT in the nucleus.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 33 | 5.26 | 6.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4064316 | — | — | 1 | 6.51 |
| CHEMBL4105629 | — | — | 1 | 5.80 |
| CHEMBL4077010 | — | — | 1 | 5.66 |
| CHEMBL4084955 | — | — | 1 | 5.53 |
| CHEMBL4079572 | — | — | 1 | 5.32 |
| CHEMBL4098505 | — | — | 1 | 5.31 |
| CHEMBL4075648 | — | — | 1 | 5.28 |
| CHEMBL4095674 | — | — | 1 | 5.16 |
| CHEMBL4091320 | — | — | 1 | 5.16 |
| CHEMBL4069163 | — | — | 1 | 5.12 |
| CHEMBL4090889 | — | — | 1 | 5.01 |
| CHEMBL4080488 | — | — | 1 | 4.68 |
| CHEMBL4072138 | — | — | 1 | 4.66 |
| CHEMBL4066607 | — | — | 1 | 4.37 |
| CHEMBL4098364 | — | — | 1 | - |
| CHEMBL4066075 | — | — | 1 | - |
| CHEMBL4095156 | — | — | 1 | - |
| CHEMBL1802401 | — | — | 1 | - |
| CHEMBL1802963 | — | — | 1 | - |
| CHEMBL4087456 | — | — | 1 | - |
| CHEMBL4065388 | — | — | 1 | - |
| CHEMBL3421979 | — | — | 1 | - |
| CHEMBL4074685 | — | — | 1 | - |
| CHEMBL4103831 | — | — | 1 | - |
| CHEMBL4095479 | — | — | 1 | - |
| CHEMBL4073997 | — | — | 1 | - |
| CHEMBL269538 | HARMINE | 1.0 | 1 | - |
| CHEMBL4094549 | — | — | 1 | - |
| CHEMBL4068096 | — | — | 1 | - |
| CHEMBL4069088 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4064316 | — | EC50 | = | 310.0 | nM | 6.51 |
| CHEMBL4105629 | — | EC50 | = | 1590.0 | nM | 5.80 |
| CHEMBL4077010 | — | EC50 | = | 2210.0 | nM | 5.66 |
| CHEMBL4084955 | — | EC50 | = | 2980.0 | nM | 5.53 |
| CHEMBL4079572 | — | EC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL4098505 | — | EC50 | = | 4850.0 | nM | 5.31 |
| CHEMBL4075648 | — | EC50 | = | 5310.0 | nM | 5.28 |
| CHEMBL4095674 | — | EC50 | = | 6960.0 | nM | 5.16 |
| CHEMBL4091320 | — | EC50 | = | 6900.0 | nM | 5.16 |
| CHEMBL4069163 | — | EC50 | = | 7580.0 | nM | 5.12 |
| CHEMBL4090889 | — | EC50 | = | 9800.0 | nM | 5.01 |
| CHEMBL4080488 | — | EC50 | = | 20820.0 | nM | 4.68 |
| CHEMBL4072138 | — | EC50 | = | 21700.0 | nM | 4.66 |
| CHEMBL4066607 | — | EC50 | = | 42980.0 | nM | 4.37 |
| CHEMBL48082 | — | EC50 | - | — | - | |
| CHEMBL4102903 | — | EC50 | - | — | - | |
| CHEMBL4086818 | — | EC50 | - | — | - | |
| CHEMBL4098364 | — | EC50 | - | — | - | |
| CHEMBL4066075 | — | EC50 | - | — | - | |
| CHEMBL4095156 | — | EC50 | - | — | - | |
| CHEMBL1802401 | — | EC50 | - | — | - | |
| CHEMBL1802963 | — | EC50 | - | — | - | |
| CHEMBL4087456 | — | EC50 | - | — | - | |
| CHEMBL4065388 | — | EC50 | - | — | - | |
| CHEMBL3421979 | — | EC50 | - | — | - | |
| CHEMBL4074685 | — | EC50 | - | — | - | |
| CHEMBL4103831 | — | EC50 | - | — | - | |
| CHEMBL4095479 | — | EC50 | - | — | - | |
| CHEMBL4073997 | — | EC50 | - | — | - | |
| CHEMBL269538 | HARMINE | EC50 | - | — | - | |
| CHEMBL4094549 | — | EC50 | - | — | - | |
| CHEMBL4068096 | — | EC50 | - | — | - | |
| CHEMBL4069088 | — | EC50 | - | — | - |