Assay Detail
Binding
CHEMBL4035080
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Antagonist activity at human TLR7 expressed in HEK293 cells assessed as inhibition of CL264-induced NF-kappaB activation after 24 hrs by spectrophotometry based SEAP reporter gene assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design and development of benzoxazole derivatives with toll-like receptor 9 antagonism.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.12 | 5.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4065452 | — | — | 1 | 5.70 |
| CHEMBL4082132 | — | — | 1 | 5.34 |
| CHEMBL4100657 | — | — | 1 | 5.33 |
| CHEMBL4067391 | — | — | 1 | 5.30 |
| CHEMBL4088644 | — | — | 1 | 5.12 |
| CHEMBL4100138 | — | — | 1 | 5.09 |
| CHEMBL4073879 | — | — | 1 | 5.08 |
| CHEMBL4071152 | — | — | 1 | 4.96 |
| CHEMBL4084216 | — | — | 1 | 4.18 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4065452 | — | IC50 | = | 1990.0 | nM | 5.70 |
| CHEMBL4082132 | — | IC50 | = | 4570.0 | nM | 5.34 |
| CHEMBL4100657 | — | IC50 | = | 4710.0 | nM | 5.33 |
| CHEMBL4067391 | — | IC50 | = | 4990.0 | nM | 5.30 |
| CHEMBL4088644 | — | IC50 | = | 7550.0 | nM | 5.12 |
| CHEMBL4100138 | — | IC50 | = | 8090.0 | nM | 5.09 |
| CHEMBL4073879 | — | IC50 | = | 8300.0 | nM | 5.08 |
| CHEMBL4071152 | — | IC50 | = | 10840.0 | nM | 4.96 |
| CHEMBL4084216 | — | IC50 | = | 66170.0 | nM | 4.18 |