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Compound Detail

CHEMBL4071152

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NC1CCN(CCCOc2ccc(-c3nc4ccc(OCCCN5CCC(N)C5)cc4o3)cc2)C1

Basic Information

ChEMBL ID CHEMBL4071152
Phase Preclinical
Structure Type MOL
InChI Key BIAMYZCEEUPXLJ-UHFFFAOYSA-N
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names

Molecular Properties

479.6
MW (Da)
3.10
ALogP
8
HBA
2
HBD
103.0
PSA (Ų)
0.40
QED
0
Ro5 Violations
11
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C27H37N5O3
MW 479.63
Aromatic Rings 3
Heavy Atoms 35
NP-Likeness -0.99

Activity Summary

IC50 2 meas. best 7.22

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Toll-like receptor 9
CHEMBL5804
IC50 7.22 7.22 60.0 1
Toll-like receptor 7
CHEMBL5936
IC50 4.96 4.96 10840.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
28437629 10.1016/j.ejmech.2017.03.086 Toll-like receptor 9 1
28437629 10.1016/j.ejmech.2017.03.086 Toll-like receptor 7 1
28437629 10.1016/j.ejmech.2017.03.086 Unchecked 1

Data from ChEMBL 36 via Core Engine