Assay Detail
Functional
CHEMBL4035279
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human UACC-903 cells harboring BRAF V600E mutant after 24 hrs by MTT assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | UACC-903 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis, and identification of a novel napthalamide-isoselenocyanate compound NISC-6 as a dual Topoisomerase-IIα and Akt pathway inhibitor, and evaluation of its anti-melanoma activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 4.82 | 5.20 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4103398 | — | — | 1 | 5.20 |
| CHEMBL43482 | MITONAFIDE | 2.0 | 1 | 4.94 |
| CHEMBL4062822 | — | — | 1 | 4.88 |
| CHEMBL4084498 | — | — | 1 | 4.87 |
| CHEMBL4100958 | — | — | 1 | 4.67 |
| CHEMBL4074200 | — | — | 1 | 4.33 |
| CHEMBL4081990 | — | — | 1 | - |
| CHEMBL1229517 | VEMURAFENIB | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4103398 | — | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL43482 | MITONAFIDE | IC50 | = | 11400.0 | nM | 4.94 |
| CHEMBL4062822 | — | IC50 | = | 13100.0 | nM | 4.88 |
| CHEMBL4084498 | — | IC50 | = | 13400.0 | nM | 4.87 |
| CHEMBL4100958 | — | IC50 | = | 21600.0 | nM | 4.67 |
| CHEMBL4074200 | — | IC50 | = | 46800.0 | nM | 4.33 |
| CHEMBL4081990 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL1229517 | VEMURAFENIB | IC50 | > | 50000.0 | nM | - |