Assay Detail
Functional
CHEMBL4035280
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human UACC-903 cells harboring BRAF V600E mutant after 48 hrs by MTT assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | UACC-903 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis, and identification of a novel napthalamide-isoselenocyanate compound NISC-6 as a dual Topoisomerase-IIα and Akt pathway inhibitor, and evaluation of its anti-melanoma activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.17 | 6.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL43482 | MITONAFIDE | 2.0 | 1 | 6.10 |
| CHEMBL4084498 | — | — | 1 | 5.60 |
| CHEMBL4103398 | — | — | 1 | 5.26 |
| CHEMBL4062822 | — | — | 1 | 5.04 |
| CHEMBL1229517 | VEMURAFENIB | 4.0 | 1 | 4.91 |
| CHEMBL4074200 | — | — | 1 | 4.89 |
| CHEMBL4100958 | — | — | 1 | 4.84 |
| CHEMBL4081990 | — | — | 1 | 4.74 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL43482 | MITONAFIDE | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL4084498 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL4103398 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL4062822 | — | IC50 | = | 9200.0 | nM | 5.04 |
| CHEMBL1229517 | VEMURAFENIB | IC50 | = | 12300.0 | nM | 4.91 |
| CHEMBL4074200 | — | IC50 | = | 12800.0 | nM | 4.89 |
| CHEMBL4100958 | — | IC50 | = | 14400.0 | nM | 4.84 |
| CHEMBL4081990 | — | IC50 | = | 18100.0 | nM | 4.74 |