Assay Detail
ADMET
CHEMBL4035319
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Inhibition of human CYP1A1 expressed in Escherichia coli DH5alpha coexpressing human NADPH P450 reductase using 7-ethoxyresorufin as substrate in presence of NADPH by fluorimetric analysis
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Inhibitors of cytochrome P450 (CYP) 1B1.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.14 | 7.39 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL279564 | PYRENE | — | 1 | 7.39 |
| CHEMBL283196 | ALPHA-NAPHTHOFLAVONE | — | 1 | 7.22 |
| CHEMBL3215302 | — | — | 1 | 6.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL279564 | PYRENE | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL283196 | ALPHA-NAPHTHOFLAVONE | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL3215302 | — | IC50 | = | 151.0 | nM | 6.82 |