Assay Detail
ADMET
CHEMBL4035320
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Inhibition of recombinant human CYP1A1 expressed in supersomes coexpressing NADPH-CYP reductase using 7-ethoxyresorufin as substrate after 15 mins in presence of NADP+ by Lineweaver-Burk plot analysis
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Inhibitors of cytochrome P450 (CYP) 1B1.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 6.64 | 6.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL498917 | — | — | 1 | 6.89 |
| CHEMBL291501 | RESVERATROL 4'-METHYL ETHER | — | 1 | 6.80 |
| CHEMBL83527 | PTEROSTILBENE | 2.0 | 1 | 6.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL498917 | — | Ki | = | 130.0 | nM | 6.89 |
| CHEMBL291501 | RESVERATROL 4'-METHYL ETHER | Ki | = | 160.0 | nM | 6.80 |
| CHEMBL83527 | PTEROSTILBENE | Ki | = | 570.0 | nM | 6.24 |