Assay Detail
Binding
CHEMBL4035321
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Inhibition of recombinant human CYP1B1 expressed in supersomes coexpressing NADPH-CYP reductase using 7-ethoxyresorufin as substrate after 15 mins in presence of NADP+ by Lineweaver-Burk plot analysis
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Inhibitors of cytochrome P450 (CYP) 1B1.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 5.97 | 6.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL165 | RESVERATROL | 3.0 | 1 | 6.10 |
| CHEMBL498917 | — | — | 1 | 6.05 |
| CHEMBL83527 | PTEROSTILBENE | 2.0 | 1 | 6.04 |
| CHEMBL291501 | RESVERATROL 4'-METHYL ETHER | — | 1 | 5.69 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL165 | RESVERATROL | Ki | = | 800.0 | nM | 6.10 |
| CHEMBL498917 | — | Ki | = | 900.0 | nM | 6.05 |
| CHEMBL83527 | PTEROSTILBENE | Ki | = | 910.0 | nM | 6.04 |
| CHEMBL291501 | RESVERATROL 4'-METHYL ETHER | Ki | = | 2060.0 | nM | 5.69 |