Assay Detail
Binding
CHEMBL4035326
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Inhibition of human CYP1B1 expressed in Escherichia coli DH5alpha coexpressing human NADPH P450 reductase using 7-ethoxyresorufin as substrate in presence of NADP+ by spectrofluorometeric analysis
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Inhibitors of cytochrome P450 (CYP) 1B1.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.23 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL309490 | GALANGIN | — | 1 | 8.52 |
| CHEMBL243664 | ACACETIN | — | 1 | 7.85 |
| CHEMBL76426 | — | — | 1 | 7.72 |
| CHEMBL294009 | FLAVONOL | — | 1 | 7.05 |
| CHEMBL16807 | 5-HYDROXYFLAVONE | — | 1 | 6.68 |
| CHEMBL276915 | 7-HYDROXYFLAVONE | — | 1 | 6.60 |
| CHEMBL275638 | FLAVONE | 2.0 | 1 | 6.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL309490 | GALANGIN | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL243664 | ACACETIN | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL76426 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL294009 | FLAVONOL | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL16807 | 5-HYDROXYFLAVONE | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL276915 | 7-HYDROXYFLAVONE | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL275638 | FLAVONE | IC50 | = | 600.0 | nM | 6.22 |