Assay Detail
Binding
CHEMBL4035329
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Inhibition of recombinant human CYP1B1 expressed in supersomes using ethoxyresorufin as substrate preincubated for 5 mins followed by substrate addition in presence of NADPH by fluorimetric analysis
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Inhibitors of cytochrome P450 (CYP) 1B1.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.79 | 7.71 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL214321 | CHRYSOERIOL | — | 1 | 7.71 |
| CHEMBL117 | CHRYSIN | — | 1 | 6.55 |
| CHEMBL151 | LUTEOLIN | 2.0 | 1 | 6.44 |
| CHEMBL28 | APIGENIN | — | 1 | 6.44 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL214321 | CHRYSOERIOL | IC50 | = | 19.7 | nM | 7.71 |
| CHEMBL117 | CHRYSIN | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL151 | LUTEOLIN | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL28 | APIGENIN | IC50 | = | 360.0 | nM | 6.44 |