Assay Detail
Binding
CHEMBL4035337
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Competitive inhibition of CYP1B1 (unknown origin) expressed in yeast microsomes using (-)benzo[a]pyrene-7R-trans-7,8-dihyrodiol (B[a]P-7,8-diol) as substrate
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Subcellular | Microsomes |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Inhibitors of cytochrome P450 (CYP) 1B1.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 5.39 | 6.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL453805 | PENTOSALEN | -1.0 | 1 | 6.00 |
| CHEMBL448060 | ISOIMPERATORIN | — | 1 | 5.22 |
| CHEMBL140796 | ISOPIMPINELLIN | — | 1 | 4.96 |
| CHEMBL1078442 | BERGAMOTTIN | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL453805 | PENTOSALEN | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL448060 | ISOIMPERATORIN | Ki | = | 6000.0 | nM | 5.22 |
| CHEMBL140796 | ISOPIMPINELLIN | Ki | = | 11000.0 | nM | 4.96 |
| CHEMBL1078442 | BERGAMOTTIN | Ki | = | 587000.0 | nM | - |