Assay Detail
Binding
CHEMBL4035350
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Inhibition of human CYP1B1 expressed in Escherichia coli DH5alpha coexpressing human NADPH-P450 reductase using 4-estradiol as substrate in presence of NADP+ by HPLC analysis
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Inhibitors of cytochrome P450 (CYP) 1B1.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.62 | 6.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL295124 | BERBERINE | 4.0 | 1 | 6.48 |
| CHEMBL1187148 | THALIDENDINE | — | 1 | 5.39 |
| CHEMBL379449 | — | — | 1 | 5.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL295124 | BERBERINE | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL1187148 | THALIDENDINE | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL379449 | — | IC50 | = | 9900.0 | nM | 5.00 |