Assay Detail
Binding
CHEMBL4035575
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]DTG from sigma-2 receptor in rat liver membranes after 120 mins by microbeta scintillation counting method
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Liver |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sigma intracellular receptor 2 (CHEMBL4105864) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Lipase-catalyzed kinetic resolution as key step in the synthesis of enantiomerically pure σ ligands with 2-benzopyran structure.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 6.67 | 7.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3828752 | — | — | 1 | 7.50 |
| CHEMBL282433 | DITOLYLGUANIDINE | — | 1 | 7.38 |
| CHEMBL4092162 | — | — | 1 | 7.17 |
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | 7.11 |
| CHEMBL4102372 | — | — | 1 | 6.58 |
| CHEMBL1169963 | — | — | 1 | 6.29 |
| CHEMBL1171865 | — | — | 1 | 6.29 |
| CHEMBL4077547 | — | — | 1 | 6.28 |
| CHEMBL1172685 | — | — | 1 | 6.21 |
| CHEMBL1169962 | — | — | 1 | 5.91 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3828752 | — | Ki | = | 32.0 | nM | 7.50 |
| CHEMBL282433 | DITOLYLGUANIDINE | Ki | = | 42.0 | nM | 7.38 |
| CHEMBL4092162 | — | Ki | = | 68.0 | nM | 7.17 |
| CHEMBL54 | HALOPERIDOL | Ki | = | 78.0 | nM | 7.11 |
| CHEMBL4102372 | — | Ki | = | 260.0 | nM | 6.58 |
| CHEMBL1169963 | — | Ki | = | 519.0 | nM | 6.29 |
| CHEMBL1171865 | — | Ki | = | 510.0 | nM | 6.29 |
| CHEMBL4077547 | — | Ki | = | 525.0 | nM | 6.28 |
| CHEMBL1172685 | — | Ki | = | 614.0 | nM | 6.21 |
| CHEMBL1169962 | — | Ki | = | 1220.0 | nM | 5.91 |