Assay Detail
Binding
CHEMBL4036010
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of jack bean urease using urea as substrate pretreated for 15 mins followed by substrate addition by phenol red based spectrophotometric method
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Canavalia ensiformis |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and molecular docking study of some 5,6-dichloro-2-cyclopropyl-1H-benzimidazole derivatives bearing triazole, oxadiazole, and imine functionalities as potent inhibitors of urease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 6.45 | 7.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4100084 | — | — | 1 | 7.30 |
| CHEMBL4092986 | — | — | 1 | 7.22 |
| CHEMBL4071196 | — | — | 1 | 6.85 |
| CHEMBL4092021 | — | — | 1 | 6.82 |
| CHEMBL4070510 | — | — | 1 | 6.77 |
| CHEMBL4103174 | — | — | 1 | 6.77 |
| CHEMBL4065321 | — | — | 1 | 6.66 |
| CHEMBL4085244 | — | — | 1 | 6.55 |
| CHEMBL4100705 | — | — | 1 | 6.54 |
| CHEMBL4074987 | — | — | 1 | 6.42 |
| CHEMBL260876 | THIOUREA | — | 1 | 6.25 |
| CHEMBL4083652 | — | — | 1 | 5.95 |
| CHEMBL4073245 | — | — | 1 | 5.87 |
| CHEMBL4073930 | — | — | 1 | 5.83 |
| CHEMBL4061886 | — | — | 1 | 5.72 |
| CHEMBL4095419 | — | — | 1 | 5.68 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4100084 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL4092986 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL4071196 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL4092021 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL4070510 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL4103174 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL4065321 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL4085244 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL4100705 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL4074987 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL260876 | THIOUREA | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL4083652 | — | IC50 | = | 1120.0 | nM | 5.95 |
| CHEMBL4073245 | — | IC50 | = | 1340.0 | nM | 5.87 |
| CHEMBL4073930 | — | IC50 | = | 1490.0 | nM | 5.83 |
| CHEMBL4061886 | — | IC50 | = | 1920.0 | nM | 5.72 |
| CHEMBL4095419 | — | IC50 | = | 2070.0 | nM | 5.68 |