Assay Detail
Binding
CHEMBL4036255
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human full length Cdc7 (1 to 574 residues)/human N-terminal GST-tagged ASK (1 to 674 residues) expressed in baculovirus expression system using N-terminal His-tagged MCM2 as substrate pretreated for 10 mins followed by ATP addition by TR-FRET assay
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase) (CHEMBL2111377) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
2-Aminomethylthieno[3,2-d]pyrimidin-4(3H)-ones bearing 3-methylpyrazole hinge binding moiety: Highly potent, selective, and time-dependent inhibitors of Cdc7 kinase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 8.23 | 9.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4083927 | — | — | 1 | 9.15 |
| CHEMBL4087760 | — | — | 1 | 8.96 |
| CHEMBL4078941 | — | — | 1 | 8.92 |
| CHEMBL4070822 | — | — | 1 | 8.85 |
| CHEMBL4080673 | — | — | 1 | 8.82 |
| CHEMBL4095460 | — | — | 1 | 8.80 |
| CHEMBL4062209 | — | — | 1 | 8.66 |
| CHEMBL4078031 | — | — | 1 | 8.62 |
| CHEMBL4084945 | — | — | 1 | 8.60 |
| CHEMBL4086790 | — | — | 1 | 8.57 |
| CHEMBL4091279 | — | — | 1 | 8.57 |
| CHEMBL4068071 | — | — | 1 | 8.57 |
| CHEMBL4103214 | — | — | 1 | 8.41 |
| CHEMBL4081417 | — | — | 1 | 8.39 |
| CHEMBL4098392 | — | — | 1 | 8.35 |
| CHEMBL4096077 | — | — | 1 | 8.33 |
| CHEMBL4091694 | — | — | 1 | 8.29 |
| CHEMBL4105646 | — | — | 1 | 8.15 |
| CHEMBL4080367 | — | — | 1 | 7.92 |
| CHEMBL4061122 | — | — | 1 | 7.82 |
| CHEMBL4099435 | — | — | 1 | 7.60 |
| CHEMBL4063842 | — | — | 1 | 7.12 |
| CHEMBL4065361 | — | — | 1 | 6.89 |
| CHEMBL4073971 | — | — | 1 | 6.85 |
| CHEMBL4062454 | — | — | 1 | 6.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4083927 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL4087760 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL4078941 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL4070822 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL4080673 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL4095460 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL4062209 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL4078031 | — | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL4084945 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL4086790 | — | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL4091279 | — | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL4068071 | — | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL4103214 | — | IC50 | = | 3.9 | nM | 8.41 |
| CHEMBL4081417 | — | IC50 | = | 4.1 | nM | 8.39 |
| CHEMBL4098392 | — | IC50 | = | 4.5 | nM | 8.35 |
| CHEMBL4096077 | — | IC50 | = | 4.7 | nM | 8.33 |
| CHEMBL4091694 | — | IC50 | = | 5.1 | nM | 8.29 |
| CHEMBL4105646 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL4080367 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL4061122 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL4099435 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL4063842 | — | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL4065361 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL4073971 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL4062454 | — | IC50 | = | 290.0 | nM | 6.54 |