Assay Detail
Binding
CHEMBL4036260
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Cdc7 in human HeLa cells assessed as reduction in MCM2 phosphorylation at ser40 residues after 7 hrs by Western blot analysis
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Cell division cycle 7-related protein kinase (CHEMBL5443) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
2-Aminomethylthieno[3,2-d]pyrimidin-4(3H)-ones bearing 3-methylpyrazole hinge binding moiety: Highly potent, selective, and time-dependent inhibitors of Cdc7 kinase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.74 | 7.17 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4080673 | — | — | 1 | 7.17 |
| CHEMBL4083927 | — | — | 1 | 6.60 |
| CHEMBL4062209 | — | — | 1 | 6.46 |
| CHEMBL4098392 | — | — | 1 | - |
| CHEMBL4080367 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4080673 | — | IC50 | = | 67.0 | nM | 7.17 |
| CHEMBL4083927 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL4062209 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL4098392 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4080367 | — | IC50 | > | 1000.0 | nM | - |