Assay Detail
Binding
CHEMBL4036300
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of bovine milk xanthine-oxidase using xanthine as substrate after 5 mins by spectrophotometric method
16
Total Activities
15
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Carboxylated aurone derivatives as potent inhibitors of xanthine oxidase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 6.52 | 8.00 |
| Inhibition | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1164729 | FEBUXOSTAT | 4.0 | 1 | 8.00 |
| CHEMBL4078467 | — | — | 2 | 7.34 |
| CHEMBL4086326 | — | — | 1 | 7.21 |
| CHEMBL4102721 | — | — | 1 | 7.21 |
| CHEMBL4066914 | — | — | 1 | 7.17 |
| CHEMBL4064851 | — | — | 1 | 7.16 |
| CHEMBL4094987 | — | — | 1 | 7.10 |
| CHEMBL4097460 | — | — | 1 | 6.82 |
| CHEMBL4093490 | — | — | 1 | 5.91 |
| CHEMBL4067565 | — | — | 1 | 5.90 |
| CHEMBL4079426 | — | — | 1 | 5.89 |
| CHEMBL4105165 | — | — | 1 | 5.80 |
| CHEMBL490355 | SULFURETIN | — | 1 | 5.51 |
| CHEMBL4087307 | — | — | 1 | 5.42 |
| CHEMBL4072779 | — | — | 1 | 5.35 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1164729 | FEBUXOSTAT | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL4078467 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL4086326 | — | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL4102721 | — | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL4066914 | — | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL4064851 | — | IC50 | = | 69.0 | nM | 7.16 |
| CHEMBL4094987 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL4097460 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL4093490 | — | IC50 | = | 1230.0 | nM | 5.91 |
| CHEMBL4067565 | — | IC50 | = | 1270.0 | nM | 5.90 |
| CHEMBL4079426 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL4105165 | — | IC50 | = | 1570.0 | nM | 5.80 |
| CHEMBL490355 | SULFURETIN | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL4087307 | — | IC50 | = | 3840.0 | nM | 5.42 |
| CHEMBL4072779 | — | IC50 | = | 4470.0 | nM | 5.35 |
| CHEMBL4078467 | — | Inhibition | - | % | - |