Assay Detail
ADMET
CHEMBL4036364
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Inhibition of recombinant human cytosolic carbonic anhydrase 1 expressed in Escherichia coli pretreated for 15 mins prior to testing by stopped-flow assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel sulfonamide-containing 2-indolinones that selectively inhibit tumor-associated alpha carbonic anhydrases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 14 | 6.40 | 7.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4104834 | — | — | 1 | 7.24 |
| CHEMBL4097126 | — | — | 1 | 7.16 |
| CHEMBL4072614 | — | — | 1 | 7.12 |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 6.60 |
| CHEMBL4099555 | — | — | 1 | 6.32 |
| CHEMBL4093328 | — | — | 1 | 6.26 |
| CHEMBL4081547 | — | — | 1 | 6.25 |
| CHEMBL4069928 | — | — | 1 | 6.21 |
| CHEMBL4061260 | — | — | 1 | 6.19 |
| CHEMBL4064015 | — | — | 1 | 6.16 |
| CHEMBL4070963 | — | — | 1 | 6.13 |
| CHEMBL4089415 | — | — | 1 | 6.05 |
| CHEMBL4080604 | — | — | 1 | 6.04 |
| CHEMBL4091812 | — | — | 1 | 5.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4104834 | — | Ki | = | 57.6 | nM | 7.24 |
| CHEMBL4097126 | — | Ki | = | 68.8 | nM | 7.16 |
| CHEMBL4072614 | — | Ki | = | 76.1 | nM | 7.12 |
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 250.0 | nM | 6.60 |
| CHEMBL4099555 | — | Ki | = | 481.0 | nM | 6.32 |
| CHEMBL4093328 | — | Ki | = | 554.4 | nM | 6.26 |
| CHEMBL4081547 | — | Ki | = | 558.0 | nM | 6.25 |
| CHEMBL4069928 | — | Ki | = | 624.2 | nM | 6.21 |
| CHEMBL4061260 | — | Ki | = | 650.0 | nM | 6.19 |
| CHEMBL4064015 | — | Ki | = | 698.0 | nM | 6.16 |
| CHEMBL4070963 | — | Ki | = | 744.0 | nM | 6.13 |
| CHEMBL4089415 | — | Ki | = | 882.0 | nM | 6.05 |
| CHEMBL4080604 | — | Ki | = | 901.0 | nM | 6.04 |
| CHEMBL4091812 | — | Ki | = | 1190.0 | nM | 5.92 |