Assay Detail
Binding
CHEMBL4036454
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Competitive inhibition of Agaricus bisporus tyrosinase assessed as reduction in diphenolase activity by measuring L-DOPA oxidation at 1.6 mM after 30 mins by Lineweaver-Burk plot
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Agaricus bisporus |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Thiosemicarbazones as inhibitors of tyrosinase enzyme.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 4.25 | 4.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL398206 | — | — | 1 | 4.30 |
| CHEMBL3190453 | — | — | 1 | 4.22 |
| CHEMBL242104 | — | — | 1 | 4.22 |
| CHEMBL4105403 | — | — | 1 | - |
| CHEMBL391982 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL398206 | — | Ki | = | 50000.0 | nM | 4.30 |
| CHEMBL3190453 | — | Ki | = | 60000.0 | nM | 4.22 |
| CHEMBL242104 | — | Ki | = | 60000.0 | nM | 4.22 |
| CHEMBL4105403 | — | Ki | = | 200000.0 | nM | - |
| CHEMBL391982 | — | Ki | = | 1300000.0 | nM | - |