Assay Detail
Binding
CHEMBL4036800
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Displacement of [3H]-N-alpha-methylhistamine from human H3R expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting analysis
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Systematic Data Mining Reveals Synergistic H3R/MCHR1 Ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 6.98 | 7.97 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL196573 | — | — | 1 | 7.97 |
| CHEMBL214957 | — | — | 1 | 6.68 |
| CHEMBL584538 | — | — | 1 | 6.29 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL196573 | — | Ki | = | 10.6 | nM | 7.97 |
| CHEMBL214957 | — | Ki | = | 208.0 | nM | 6.68 |
| CHEMBL584538 | — | Ki | = | 516.7 | nM | 6.29 |