Assay Detail
Binding
CHEMBL4036813
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Inhibition of full length human TRPA1 at a holding potential of 15 mV measured after 1 min by PatchXpress electrophysiology assay
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Transient receptor potential cation channel subfamily A member 1 (CHEMBL6007) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of a Series of Indazole TRPA1 Antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 6.38 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4062193 | — | — | 1 | 7.70 |
| CHEMBL4103611 | — | — | 1 | 7.42 |
| CHEMBL4095993 | — | — | 1 | 7.38 |
| CHEMBL4098431 | — | — | 1 | 7.28 |
| CHEMBL4063630 | — | — | 1 | 7.13 |
| CHEMBL4091459 | — | — | 1 | 7.04 |
| CHEMBL4088258 | — | — | 1 | 6.96 |
| CHEMBL4060024 | — | — | 1 | 6.88 |
| CHEMBL4073272 | — | — | 1 | 6.87 |
| CHEMBL4067095 | — | — | 1 | 6.59 |
| CHEMBL4102407 | — | — | 1 | 6.35 |
| CHEMBL4093377 | — | — | 1 | 6.26 |
| CHEMBL4072845 | — | — | 1 | 6.19 |
| CHEMBL4101680 | — | — | 1 | 6.16 |
| CHEMBL4100238 | — | — | 1 | 6.13 |
| CHEMBL4083680 | — | — | 1 | 5.93 |
| CHEMBL4061022 | — | — | 1 | 5.92 |
| CHEMBL4061751 | — | — | 1 | 5.68 |
| CHEMBL4067996 | — | — | 1 | 5.60 |
| CHEMBL4075615 | — | — | 1 | 5.57 |
| CHEMBL4082907 | — | — | 1 | 5.43 |
| CHEMBL4079870 | — | — | 1 | 5.33 |
| CHEMBL4080409 | — | — | 1 | 4.93 |
| CHEMBL4079487 | — | — | 1 | - |
| CHEMBL4103736 | — | — | 1 | - |
| CHEMBL4068678 | — | — | 1 | - |
| CHEMBL4072661 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4062193 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL4103611 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL4095993 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL4098431 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL4063630 | — | IC50 | = | 74.0 | nM | 7.13 |
| CHEMBL4091459 | — | IC50 | = | 91.0 | nM | 7.04 |
| CHEMBL4088258 | — | IC50 | = | 111.0 | nM | 6.96 |
| CHEMBL4060024 | — | IC50 | = | 131.0 | nM | 6.88 |
| CHEMBL4073272 | — | IC50 | = | 134.0 | nM | 6.87 |
| CHEMBL4067095 | — | IC50 | = | 257.0 | nM | 6.59 |
| CHEMBL4102407 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL4093377 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL4072845 | — | IC50 | = | 645.0 | nM | 6.19 |
| CHEMBL4101680 | — | IC50 | = | 686.0 | nM | 6.16 |
| CHEMBL4100238 | — | IC50 | = | 748.0 | nM | 6.13 |
| CHEMBL4083680 | — | IC50 | = | 1182.0 | nM | 5.93 |
| CHEMBL4061022 | — | IC50 | = | 1203.0 | nM | 5.92 |
| CHEMBL4061751 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL4067996 | — | IC50 | = | 2537.0 | nM | 5.60 |
| CHEMBL4075615 | — | IC50 | = | 2667.0 | nM | 5.57 |
| CHEMBL4082907 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL4079870 | — | IC50 | = | 4630.0 | nM | 5.33 |
| CHEMBL4080409 | — | IC50 | = | 11700.0 | nM | 4.93 |
| CHEMBL4079487 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4103736 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4068678 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4072661 | — | IC50 | > | 10000.0 | nM | - |