Assay Detail
Binding
CHEMBL4037091
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at human GST-tagged IGF-1R (950 to 133 residues) expressed in baculovirus after 5 mins in presence of [gamma33P]-ATP by top count method
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Insulin-like growth factor 1 receptor (CHEMBL1957) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Natural-Products-Inspired Use of the gem-Dimethyl Group in Medicinal Chemistry.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.18 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4096340 | — | — | 1 | 8.00 |
| CHEMBL1614712 | — | — | 1 | 7.22 |
| CHEMBL3787614 | — | — | 1 | 7.10 |
| CHEMBL3787112 | — | — | 1 | 6.38 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4096340 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL1614712 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL3787614 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL3787112 | — | IC50 | = | 420.0 | nM | 6.38 |