Assay Detail
Functional
CHEMBL4037290
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV 1 isolate JRFL by single cycle infectivity assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Inhibitors of HIV-1 Attachment: The Discovery and Development of Temsavir and its Prodrug Fostemsavir.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 10 | 9.54 | 10.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2332330 | — | — | 1 | 10.15 |
| CHEMBL2332324 | — | — | 1 | 10.05 |
| CHEMBL4069670 | — | — | 1 | 9.96 |
| CHEMBL3301620 | TEMSAVIR | 2.0 | 1 | 9.85 |
| CHEMBL2332326 | — | — | 1 | 9.82 |
| CHEMBL4104608 | — | — | 1 | 9.68 |
| CHEMBL4089174 | — | — | 1 | 9.39 |
| CHEMBL4080382 | — | — | 1 | 9.11 |
| CHEMBL4066957 | — | — | 1 | 8.89 |
| CHEMBL2332327 | — | — | 1 | 8.45 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2332330 | — | EC50 | = | 0.07 | nM | 10.15 |
| CHEMBL2332324 | — | EC50 | = | 0.09 | nM | 10.05 |
| CHEMBL4069670 | — | EC50 | = | 0.11 | nM | 9.96 |
| CHEMBL3301620 | TEMSAVIR | EC50 | = | 0.14 | nM | 9.85 |
| CHEMBL2332326 | — | EC50 | = | 0.15 | nM | 9.82 |
| CHEMBL4104608 | — | EC50 | = | 0.21 | nM | 9.68 |
| CHEMBL4089174 | — | EC50 | = | 0.41 | nM | 9.39 |
| CHEMBL4080382 | — | EC50 | = | 0.78 | nM | 9.11 |
| CHEMBL4066957 | — | EC50 | = | 1.3 | nM | 8.89 |
| CHEMBL2332327 | — | EC50 | = | 3.56 | nM | 8.45 |