Assay Detail

CHEMBL4037293

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Functional

Antiviral activity against HIV-1 Bal infected in human PM1 cells harboring CCR5 co-receptor after 4 to 6 days by p24 ELISA

ChEMBL ↗

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Target

Human immunodeficiency virus 1 (CHEMBL378) ↗

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Primary target Human immunodeficiency virus 1

CHEMBL378

Anchored from Assay target.

Protein identity Human immunodeficiency virus 1

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Human immunodeficiency virus 1
Confidence	1 — Organism
Curated By	Autocuration

Target

Human immunodeficiency virus 1 (CHEMBL378) ↗

Type	ORGANISM
Organism	Human immunodeficiency virus 1

Publication

Inhibitors of HIV-1 Attachment: The Discovery and Development of Temsavir and its Prodrug Fostemsavir.

Meanwell NA, Krystal MR, Nowicka-Sans B, Langley DR, Conlon DA, Eastgate MD, Grasela DM, Timmins P, Wang T, Kadow JF.
J Med Chem (2018) 61 : 62 -80
PubMed 29271653 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
EC50	2	8.21	8.77

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL3301620	TEMSAVIR	2.0	1	8.77
CHEMBL238103	—	—	1	7.64

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL3301620	TEMSAVIR	EC50	=	1.7	nM	8.77
CHEMBL238103	—	EC50	=	23.0	nM	7.64