Assay Detail
Functional
CHEMBL4037508
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at mGlu4 assessed as decrease in PF-induced presynaptic calcium amplitude in rat coronal slices by Fluo-4FF-AM dye based fluorescence assay
3
Total Activities
1
Compounds Tested
3
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Metabotropic glutamate receptor 4 (CHEMBL2787) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Increased Potency and Selectivity for Group III Metabotropic Glutamate Receptor Agonists Binding at Dual sites.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 1 | 4.70 | 4.70 |
| Activity | 1 | - | - |
| Imax | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3114672 | — | — | 3 | 4.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3114672 | — | EC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL3114672 | — | Activity | - | — | - | |
| CHEMBL3114672 | — | Imax | = | 40.0 | % | - |