Metabotropic glutamate receptor 4 · SINGLE PROTEIN · Rattus norvegicus
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As of 2026-09-14Protein identity stays anchored to UniProt P31423. Use UniProt P31423 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P31423 as the stable identity anchor, then attach disease evidence before program review.
Metabotropic glutamate receptor 4
Review this target as Metabotropic glutamate receptor 4, mapped to UniProt P31423. Sequence length is 912 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Metabotropic glutamate receptor 4 as ChEMBL target CHEMBL2787, mapped to UniProt P31423. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Metabotropic glutamate receptor 4 |
| Target Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
| UniProt | P31423 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Metabotropic glutamate receptor 4 |
| UniProt Accession | P31423 |
| Component Type | Protein |
| Sequence Length | 912 aa |
Metabotropic glutamate receptor 4
Review this target as Metabotropic glutamate receptor 4, mapped to UniProt P31423. Sequence length is 912 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL3357575 | 8.38 | IC50 | 4.169 | Preclinical |
| CHEMBL3357574 | 8.29 | IC50 | 5.1 | Preclinical |
| CHEMBL3609729 | 8.05 | EC50 | 9.0 | Preclinical |
| CHEMBL541754 | 8.0 | IC50 | 9.9 | Preclinical |
| CHEMBL3357576 | 7.93 | IC50 | 11.75 | Preclinical |
| CHEMBL562551 | 7.89 | IC50 | 12.8 | Preclinical |
| CHEMBL3114673 | 7.62 | EC50 | 24.0 | Preclinical |
| CHEMBL3357577 | 7.58 | IC50 | 26.3 | Preclinical |
| CHEMBL4067875 | 7.57 | EC50 | 27.0 | Preclinical |
| CHEMBL229697 | 7.52 | EC50 | 30.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 39 | 67 | 6.7 |
| single protein format | 21 | 26 | 6.2 |
| assay format | 3 | 7 | 5.5 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 48 | 115 | 5.9 |
| assay format | 9 | 7 | 5.7 |