Compound Detail
CHEMBL3357576
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Basic Information
| ChEMBL ID | CHEMBL3357576 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | KMESJSGTUSEKQW-UHFFFAOYSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
456.7
MW (Da)
4.55
ALogP
4
HBA
1
HBD
79.4
PSA (Ų)
0.59
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 7.93
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Metabotropic glutamate receptor 4 CHEMBL2787 | IC50 | 7.93 | 7.93 | 11.8 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Metabotropic glutamate receptor 4 | IC50 | = | 11.8 | nM | 7.93 | Displacement of [3H]ML128 from rat mGlu4 receptor expressed in CHO cells after 3... | 25330258 |
| Metabotropic glutamate receptor 4 | IC50 | = | 11.75 | nM | 7.93 | Displacement of [3H]ML128 from rat mGlu4 receptor expressed in CHO cells after 3... | 25330258 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 25330258 | 10.1021/jm501245b | Metabotropic glutamate receptor 4 | 3 |
Data from ChEMBL 36 via Core Engine