Assay Detail
Binding
CHEMBL4038125
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human plasma kallikrein using fluorogenic H-Pro-Phe-Arg-AMC peptide as substrate preincubated for 15 mins followed by substrate addition measured by fluorescence-based assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Stable and Long-Lasting, Novel Bicyclic Peptide Plasma Kallikrein Inhibitors for the Treatment of Diabetic Macular Edema.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 13 | 9.40 | 10.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4089486 | — | — | 1 | 10.22 |
| CHEMBL4079711 | — | — | 1 | 10.15 |
| CHEMBL4099333 | — | — | 1 | 9.85 |
| CHEMBL4093698 | — | — | 1 | 9.82 |
| CHEMBL4076199 | — | — | 1 | 9.68 |
| CHEMBL4070056 | — | — | 1 | 9.60 |
| CHEMBL4094403 | — | — | 1 | 9.44 |
| CHEMBL4079260 | — | — | 1 | 9.41 |
| CHEMBL4085408 | — | — | 1 | 9.36 |
| CHEMBL4088185 | — | — | 1 | 8.89 |
| CHEMBL4105318 | — | — | 1 | 8.68 |
| CHEMBL4075544 | — | — | 1 | 8.64 |
| CHEMBL4059991 | — | — | 1 | 8.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4089486 | — | Ki | = | 0.06 | nM | 10.22 |
| CHEMBL4079711 | — | Ki | = | 0.07 | nM | 10.15 |
| CHEMBL4099333 | — | Ki | = | 0.14 | nM | 9.85 |
| CHEMBL4093698 | — | Ki | = | 0.15 | nM | 9.82 |
| CHEMBL4076199 | — | Ki | = | 0.21 | nM | 9.68 |
| CHEMBL4070056 | — | Ki | = | 0.25 | nM | 9.60 |
| CHEMBL4094403 | — | Ki | = | 0.36 | nM | 9.44 |
| CHEMBL4079260 | — | Ki | = | 0.39 | nM | 9.41 |
| CHEMBL4085408 | — | Ki | = | 0.44 | nM | 9.36 |
| CHEMBL4088185 | — | Ki | = | 1.3 | nM | 8.89 |
| CHEMBL4105318 | — | Ki | = | 2.1 | nM | 8.68 |
| CHEMBL4075544 | — | Ki | = | 2.3 | nM | 8.64 |
| CHEMBL4059991 | — | Ki | = | 3.0 | nM | 8.52 |