Assay Detail
Binding
CHEMBL4038148
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human C-terminal 10His-tagged factor Xa (24 to 488 residues) expressed in baculovirus derived insect sf21 cells using fluorogenic Mca-RPKPVE-Nval-WRK(Dnp)-NH2 peptide as substrate by fluorescence based assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Stable and Long-Lasting, Novel Bicyclic Peptide Plasma Kallikrein Inhibitors for the Treatment of Diabetic Macular Edema.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 4.64 | 4.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4070056 | — | — | 1 | 4.64 |
| CHEMBL4059991 | — | — | 1 | - |
| CHEMBL4094403 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4070056 | — | Ki | = | 23000.0 | nM | 4.64 |
| CHEMBL4059991 | — | Ki | > | 50000.0 | nM | - |
| CHEMBL4094403 | — | Ki | > | 50000.0 | nM | - |