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Assay Detail

CHEMBL4038374

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiprotozoal activity against bloodstream form of Trypanosoma brucei rhodesiense STIB900 after 72 hrs by Alamar Blue assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Trypanosoma brucei rhodesiense
Confidence 1 — Organism
Curated By Autocuration

Target

Trypanosoma brucei rhodesiense (CHEMBL612348)
Type ORGANISM
Organism Trypanosoma brucei rhodesiense

Publication

Antiprotozoal Activity-Based Profiling of a Dichloromethane Extract from Anthemis nobilis Flowers.
De Mieri M, Monteleone G, Ismajili I, Kaiser M, Hamburger M.
J Nat Prod (2017) 80 : 459 -470
PubMed 28116906 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 14 6.26 8.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL166 MELARSOPROL 3.0 1 8.00
CHEMBL4076328 1 7.10
CHEMBL4076244 1 6.44
CHEMBL4070082 1 6.40
CHEMBL4075374 1 6.40
CHEMBL4059870 1 6.38
CHEMBL4068842 1 6.21
CHEMBL4080773 1 6.06
CHEMBL4076872 1 5.92
CHEMBL4101872 1 5.92
CHEMBL4094141 1 5.89
CHEMBL4070737 1 5.85
CHEMBL4103119 1 5.68
CHEMBL4076635 1 5.34

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL166 MELARSOPROL IC50 = 10.0 nM 8.00
CHEMBL4076328 IC50 = 80.0 nM 7.10
CHEMBL4076244 IC50 = 360.0 nM 6.44
CHEMBL4070082 IC50 = 400.0 nM 6.40
CHEMBL4075374 IC50 = 400.0 nM 6.40
CHEMBL4059870 IC50 = 420.0 nM 6.38
CHEMBL4068842 IC50 = 610.0 nM 6.21
CHEMBL4080773 IC50 = 880.0 nM 6.06
CHEMBL4076872 IC50 = 1200.0 nM 5.92
CHEMBL4101872 IC50 = 1200.0 nM 5.92
CHEMBL4094141 IC50 = 1300.0 nM 5.89
CHEMBL4070737 IC50 = 1400.0 nM 5.85
CHEMBL4103119 IC50 = 2100.0 nM 5.68
CHEMBL4076635 IC50 = 4600.0 nM 5.34