Assay Detail
Binding
CHEMBL4038422
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Binding affinity to BRD2 BD1-BD2 (G73 to A560 residues) (unknown origin) after 1 hr by Alexa-647-conjugated probe based TR-FRET assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Methylpyrrole inhibitors of BET bromodomains.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 7.41 | 7.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4063051 | — | — | 1 | 7.85 |
| CHEMBL3786012 | — | — | 1 | 7.57 |
| CHEMBL4088466 | — | — | 1 | 6.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4063051 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL3786012 | — | Ki | = | 27.0 | nM | 7.57 |
| CHEMBL4088466 | — | Ki | = | 160.0 | nM | 6.80 |