Assay Detail
Binding
CHEMBL4038425
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to BRD4 BD2 (E352 to M457 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) after 1 hr by Alexa-647-conjugated probe based TR-FRET assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Methylpyrrole inhibitors of BET bromodomains.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 7.13 | 7.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4063051 | — | — | 1 | 7.42 |
| CHEMBL3786012 | — | — | 1 | 7.42 |
| CHEMBL4088466 | — | — | 1 | 6.55 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4063051 | — | Ki | = | 38.0 | nM | 7.42 |
| CHEMBL3786012 | — | Ki | = | 38.0 | nM | 7.42 |
| CHEMBL4088466 | — | Ki | = | 280.0 | nM | 6.55 |