Assay Detail
Binding
CHEMBL4040030
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of porcupine (unknown origin)
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Protein-serine O-palmitoleoyltransferase porcupine (CHEMBL1255163) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Scaffold Hopping and Optimization of Maleimide Based Porcupine Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 8.39 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3188386 | WNT-974 | 2.0 | 1 | 9.40 |
| CHEMBL3633802 | ETC-159 | 1.0 | 1 | 8.54 |
| CHEMBL4088085 | — | — | 1 | 7.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3188386 | WNT-974 | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL3633802 | ETC-159 | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL4088085 | — | IC50 | = | 60.0 | nM | 7.22 |